Thursday, October 31, 2013

FAA to allow use of electronics for entire flights


Globe-trotting laptop workaholics and electronic media junkies will soon no longer fidget helplessly during the beginning and ending of their flights: The U.S. Federal Aviation Administration (FAA) has lifted the ban on use of personal electronics during the take-off and landing of airplanes, provided that the electronic devices are used in airplane mode.


Over the next few months, each airline will enact their own policies that will permit their passengers to use their own devices through an entire flight.


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Airplane passengers, in most cases, will be able to read electronic books and magazines, watch videos, play video games, listen to music and work on their computers throughout an entire flight.


Their devices must be in airplane mode, however, which will not allow them to be used voice communications or data transmission through mobile networks. The devices can, however, connect with an airplane's Wi-Fi service, if one is offered. Short-range, device-to-device communication, through Bluetooth for instance, is also permissible.


This change in policy has been long called for, at least by voracious users of electronic devices, who saw the ban as unnecessary.


Currently, airline passengers in the U.S. are required power down their smartphones, tablets, laptops and electronic readers when the airplane is taking off or landing.


Since people started bringing personal electronic communication devices on flights, the FAA assumed a cautious stance of limiting their use, fearing the devices would interfere with the airplane's radio frequency communications.


The FAA's Personal Electronic Device Aviation Rulemaking Committee concluded in a report earlier this year that most commercial airplanes can tolerate radio interference signals from portable devices. For the new ruling, the FAA also took feedback from airlines, aviation manufacturers, passengers, pilots, flight attendants and the mobile technology industry.


Mobile phone communications falls under the jurisdiction of the U.S. Federal Communications Commission, which the FAA has urged to review its rules on in-flight use. Unlike other mobile electronic operations, cell phones send out relatively powerful signals that could interfere with in-flight radio communications.


Even devices that do not transmit signals can hamper a plane's communications, navigation, flight control and electronic equipment because they may emit radio energy at the same frequencies as the plane's equipment.


The airlines should determine how much radio interference their own communications systems can withstand. The airlines must then set their own conditions for usage and get FAA approval for these conditions.


The current FAA policy will remain in effect on an airline-by-airline basis until the FAA gives each airline approval to switch to the new policy.


Even after the new policy is adopted, an airline may also need to have their passengers shut down their devices during periods of low visibility to ensure adequate communications in such adverse conditions. The FAA expects that such conditions would apply to about one percent of all flights.


Joab Jackson covers enterprise software and general technology breaking news for The IDG News Service. Follow Joab on Twitter at @Joab_Jackson. Joab's e-mail address is Joab_Jackson@idg.com


Source: http://www.infoworld.com/t/federal-regulations/faa-allow-use-of-electronics-entire-flights-229948?source=rss_mobile_technology
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'Amazing Spider-Man 2': Meet The Soundtrack's Sinister Six


Pharrell and the dudes from the Smiths, Eurythmics and Incubus team up with director Marc Webb and composer Hans Zimmer.


By Alex Zalben








Source:
http://www.mtv.com/news/articles/1716623/amazing-spider-man-2-soundtrack-pharrell.jhtml

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Toronto police say they have mayor drug video

Mayor Rob Ford walks past Halloween decorations on his way to talk to media at City Hall in Toronto on Thursday, Oct. 31, 2013. Ford says he has no reason to step down despite police confirmation that they have seized a video that appears to show him smoking a crack pipe. (AP Photo/The Canadian Press, Frank Gunn)







Mayor Rob Ford walks past Halloween decorations on his way to talk to media at City Hall in Toronto on Thursday, Oct. 31, 2013. Ford says he has no reason to step down despite police confirmation that they have seized a video that appears to show him smoking a crack pipe. (AP Photo/The Canadian Press, Frank Gunn)







Mayor Rob Ford talks to media at City Hall in Toronto on Thursday, Oct. 31, 2013. Ford that appears to show him smoking a crack pipe. (AP Photo/The Canadian Press, Frank Gunn)







Toronto Mayor Rob Ford addresses media outside his office in Toronto on Thursday, Oct. 31, 2013. Ford says he has no reason to step down despite police confirmation that they have seized a video that appears to show him smoking a crack pipe.(AP Photo/The Canadian Press, Nathan Denette)







These annotated video frame grab images provided by the Toronto Police Service on Thursday, Oct. 31, 2013, show Toronto Mayor Rob Ford, left, and his close friend, Alexander Lisi. Police say they rummaged through Ford's garbage and conducted a massive surveillance operation monitoring him and Lisi following drug use allegations. The marks seen on the images were drawn by the police. (AP Photo/Toronto Police Service via The Canadian Press)







This annotated video frame grab image provided by the Toronto Police Service on Thursday, Oct. 31, 2013, shows Toronto Mayor Rob Ford, left, and his close friend, Alexander Lisi. Police say they rummaged through Ford's garbage and conducted a massive surveillance operation monitoring him and Lisi following drug use allegations. The marks seen on the images were drawn by the police. (AP Photo/Toronto Police Service via The Canadian Press)







(AP) — Toronto police said Thursday they have obtained a video that appears to show Mayor Rob Ford smoking a crack pipe — a video that Ford had claimed didn't exist and has been at the core of a scandal that has embarrassed and gripped Canada for months.

Police Chief Bill Blair said the video, recovered after being deleted from a computer hard drive, did not provide grounds to press charges. Ford, a populist mayor who has repeatedly made headlines for his bizarre behavior, vowed not to resign.

Speaking outside the door his office, where visitors were free to check out the Halloween decorations, Ford said with a smile: "I have no reason to resign." He said he couldn't defend himself because the affair is part of a criminal investigation involving an associate, adding: "That's all I can say right now." Toronto police discovered the video while conducting a huge surveillance operation into a friend and sometimes driver suspected of providing Ford with drugs.

Ford faced allegations in May that he had been caught on video puffing from a glass crack pipe. Two reporters with the Toronto Star said they saw the video, but it has not been released publicly. Ford maintained he does not smoke crack and that the video did not exist.

The scandal has been the fodder of jokes on U.S. late night television and has cast Canada's largest city and financial capital in an unflattering light.

Ford was elected mayor three years ago on a wave of discontent simmering in the city's outlying suburbs. Since then he has survived an attempt to remove him from office on conflict-of-interest charges and has appeared in the news for his increasingly odd behavior. Through it all, the mayor has repeatedly refused to resign and pledged to run for re-election next year.

But the pressure ramped up on Thursday with all four major dailies in the city calling on Ford to resign.

Cheri DiNovo, a member of Ontario's parliament, tweeted: "Ford video nothing to celebrate Addiction is illness. Mayor please step down and get help?"

On Thursday, Blair said the video of the mayor "depicts images that are consistent with those previously reported in the press."

"As a citizen of Toronto I'm disappointed," Blair said. "This is a traumatic issue for citizens of this city and the reputation of this city."

Blair said the video will come out when Ford's associate and occasional driver, Alexander Lisi, goes to trial on drug charges. Lisi now also faces extortion charges for trying to retrieve the recording from an unidentified person. Blair did not say who owned the computer containing the video.

Blair said authorities believed the video is linked to a home in Toronto, referred to by a confidential informant as a "crack house" in court documents in Lisi's drug case.

The prosecutor in the Lisi case released documents Thursday showing they had rummaged through Ford's garbage in search of evidence of drug use. They show that they conducted a massive surveillance operation monitoring the mayor and Lisi following drug use allegations.

The documents show that friends and former staffers of Ford were concerned that Lisi was "fuelling" the Toronto mayor's alleged drug use.

The police documents, ordered released by a judge, show Ford receiving packages from Lisi on several occasions.

"Lisi approached the driver's side of the Mayor's vehicle with a small white gift bag in hand; he then walked around to the passenger side and got on board," reads one document dated July 30, 2013. "After a few minutes Lisi exited the Escalade empty handed and walked back to his Range Rover."

Another dated July 28 says Lisi "constantly used counter surveillance techniques" when he met with Ford that day.

On August 13 documents say Lisi and Ford met and "made their way into a secluded area of the adjacent woods where they were obscured from surveillance efforts and stayed for approximately one hour."

Ford recently vouched for Lisi in a separate criminal case, praising his leadership skills and hard work in a letter filed with the court. The letter was part of a report prepared by a probation officer after Lisi was convicted of threatening to kill a woman.

Ford said previously that he was shocked when Lisi was arrested earlier this month, calling him a "good guy" and saying he doesn't abandon his friends.

The documents also say that Ford met Lisi through Payman Aboodowleh, a volunteer football coach at Don Bosco Catholic Secondary School, where Ford coached the team while also serving as mayor. He told police he was "mad at Lisi because he was fuelling the mayor's drug abuse," the document says.

Ford's controversies range from the trivial to the serious: Walking face-first into a TV camera. Falling down during a photo op while pretending to play football. Being asked to leave an event for wounded war vets because he appeared intoxicated, according to the Toronto Star. Being forced to admit he was busted for marijuana possession in Florida in 1999, after repeated denials. Making rude gestures at Torontonians from his car.

Ford was fired earlier this year from his beloved volunteer job coaching football over disparaging remarks he made to a TV network about parents and their kids at the school.

"The mayor has said there wasn't a video," Toronto councilor Paula Fletcher said. "He has said there is a conspiracy against him. With Chief's Blair's press conference I think that's put to rest."

Associated PressSource: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-10-31-Canada-Toronto%20Mayor/id-45dff419b74240959ed40163412d183b
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Pumpkins replace politics at White House Halloween


WASHINGTON (AP) — Finally, the White House has pulled off a successful web launch.

Ghastly webs with giant black spiders adorned an orange-hued White House on Thursday, slithering down from the Truman Balcony along the South Portico, where haystacks and nearly 200 pumpkins dotted the lawn for the annual White House Halloween event.

President Barack Obama and first lady Michelle Obama, clad in orange and black, emerged in the evening to greet the zombies, wizards and superheroes waiting diligently to hear the president's response to an eerie query: Trick or treat?

It was treats — thousands of packages of jelly beans, dried fruit and White House Sweet Dough Butter Cookies — that the president and Mrs. Obama handed children as they walked across the South Lawn, past stilt-walkers, jugglers and a giant, transparent bubble housing Glinda the Good Witch, who brandished her magic wand in true Wizard-of-Oz fashion.

Fog billowed across the lawn, obscuring the Washington Monument in the distance as children and their parents mingled with White House staffers dressed as football players, vampires and princesses. A brass band of white-faced skeletons set the mood with creepy Halloween tunes, dancing as they played alongside a family of ghosts camped out near the area where the president's helicopter normally lifts off.

Even the president's dogs donned costumes — no, not the real Sunny and Bo, but topiaries carved from ribbons and pipe cleaners and dressed up, Bo as a pirate and Sunny as a sunflower.

The festivities marked the return of a favorite annual tradition at the White House that had to be scrapped last year. After three straight years of passing out goodies, rain or shine, Obama and the first lady canceled the event last year because of Superstorm Sandy, which had walloped the East Coast earlier in the week.

More than 5,000 people took part in this year's event, the White House said.

___

Reach Josh Lederman on Twitter at http://twitter.com/joshledermanAP

Source: http://news.yahoo.com/pumpkins-replace-politics-white-house-halloween-223031870.html
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Biochemists find incomplete protein digestion is a useful thing for some bacteria

Biochemists find incomplete protein digestion is a useful thing for some bacteria


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Contact: Janet Lathrop
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University of Massachusetts at Amherst



To the authors' surprise, 1 specialized replication factor was partially digested or trimmed, physically cut into shorter fragments, by an energy-dependent protease known as ClpXP, which generates specific-sized fragments essential for normal growth




AMHERST, Mass. Usually indigestion is a bad thing, but experiments by researcher Peter Chien and graduate student Robert Vass at the University of Massachusetts Amherst recently showed that for the bacteria Caulobacter crescentus, partial degradation of a DNA replication protein is required to keep it alive.


DNA replication is one of the most highly controlled biological processes in all organisms, says Chien, an assistant professor of biochemistry and molecular biology at UMass Amherst. From humans all the way back to bacteria, all cells must faithfully duplicate their genomes in order to survive. To coordinate the start, ensure the completion and repair damages during DNA replication, specialized proteins play a key role by regulating processes.


In work published this month in Proceedings of the National Academy of Sciences, Chien and Vass report that one of these specialized replication factors, DnaX, is, to their surprise, partially digested or trimmed, physically cut into shorter fragments, by an energy-dependent protease known as ClpXP, which generates specific-sized fragments that are essential for Caulobacter's normal growth.


The phenomenon isn't entirely unknown, Chien explains. Short as well as long versions of DnaX had been observed 20 years ago in another bacteria, E. coli. But in E. coli, the short form was produced by changes in translation due to an early ribosome stop at a specific RNA sequence. That RNA sequence is absent in many bacteria DnaX genes including in Caulobacter, so scientists long thought that short DnaX only existed in bacteria like E. coli.


Based on previous studies in his lab, Chien and Vass moved on to investigate, by purifying these proteins and testing their activity in Caulobacter in vivo, whether the protein DnaX could be degraded by the protease ClpXP. To their surprise, ClpXP did recognize DnaX, but only partially degraded it, generating stable shorter fragments both in vitro and in vivo.


Further, they found that both long and short forms were essential for normal growth and that the short form was particularly important for DNA damage tolerance, suggesting that these fragments are not accidental but are made in a programmed manner.


Vass and Chien's new work shows that in some bacteria, short forms of DnaX are made instead by another method, proteolysis, with dramatic consequences for the cell, the biochemist says. "This type of convergent evolution results in similar protein outcomes, that is the generation of two forms through radically different mechanisms. This suggests that both long and short forms are crucial for all bacteria," he adds.


Protein degradation by energy-dependent proteases normally results in the complete destruction of target proteins, Chien notes. However, under particularly harsh artificial conditions in the test tube, these proteases can stall on certain targets. But until the recent UMass Amherst experiments, such an effect had never been seen inside a living bacterial cell, he adds.


Chien feels this mode of partial digestion could be useful in other bacteria to generate new functions from existing proteins and increasing the ability of a single gene to encode for multiple protein functions. This work was supported by NIH's National Institute for General Medical Sciences and by UMass Amherst.


###


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Biochemists find incomplete protein digestion is a useful thing for some bacteria


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31-Oct-2013



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Contact: Janet Lathrop
jlathrop@admin.umass.edu
413-545-0444
University of Massachusetts at Amherst



To the authors' surprise, 1 specialized replication factor was partially digested or trimmed, physically cut into shorter fragments, by an energy-dependent protease known as ClpXP, which generates specific-sized fragments essential for normal growth




AMHERST, Mass. Usually indigestion is a bad thing, but experiments by researcher Peter Chien and graduate student Robert Vass at the University of Massachusetts Amherst recently showed that for the bacteria Caulobacter crescentus, partial degradation of a DNA replication protein is required to keep it alive.


DNA replication is one of the most highly controlled biological processes in all organisms, says Chien, an assistant professor of biochemistry and molecular biology at UMass Amherst. From humans all the way back to bacteria, all cells must faithfully duplicate their genomes in order to survive. To coordinate the start, ensure the completion and repair damages during DNA replication, specialized proteins play a key role by regulating processes.


In work published this month in Proceedings of the National Academy of Sciences, Chien and Vass report that one of these specialized replication factors, DnaX, is, to their surprise, partially digested or trimmed, physically cut into shorter fragments, by an energy-dependent protease known as ClpXP, which generates specific-sized fragments that are essential for Caulobacter's normal growth.


The phenomenon isn't entirely unknown, Chien explains. Short as well as long versions of DnaX had been observed 20 years ago in another bacteria, E. coli. But in E. coli, the short form was produced by changes in translation due to an early ribosome stop at a specific RNA sequence. That RNA sequence is absent in many bacteria DnaX genes including in Caulobacter, so scientists long thought that short DnaX only existed in bacteria like E. coli.


Based on previous studies in his lab, Chien and Vass moved on to investigate, by purifying these proteins and testing their activity in Caulobacter in vivo, whether the protein DnaX could be degraded by the protease ClpXP. To their surprise, ClpXP did recognize DnaX, but only partially degraded it, generating stable shorter fragments both in vitro and in vivo.


Further, they found that both long and short forms were essential for normal growth and that the short form was particularly important for DNA damage tolerance, suggesting that these fragments are not accidental but are made in a programmed manner.


Vass and Chien's new work shows that in some bacteria, short forms of DnaX are made instead by another method, proteolysis, with dramatic consequences for the cell, the biochemist says. "This type of convergent evolution results in similar protein outcomes, that is the generation of two forms through radically different mechanisms. This suggests that both long and short forms are crucial for all bacteria," he adds.


Protein degradation by energy-dependent proteases normally results in the complete destruction of target proteins, Chien notes. However, under particularly harsh artificial conditions in the test tube, these proteases can stall on certain targets. But until the recent UMass Amherst experiments, such an effect had never been seen inside a living bacterial cell, he adds.


Chien feels this mode of partial digestion could be useful in other bacteria to generate new functions from existing proteins and increasing the ability of a single gene to encode for multiple protein functions. This work was supported by NIH's National Institute for General Medical Sciences and by UMass Amherst.


###


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Source: http://www.eurekalert.org/pub_releases/2013-10/uoma-bfi103113.php
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Newly identified proteins make promising targets for blocking graft-vs.-host disease

Newly identified proteins make promising targets for blocking graft-vs.-host disease


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Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System



Finding could help improve outcomes from bone marrow transplants




ANN ARBOR, Mich. Researchers from the University of Michigan Comprehensive Cancer Center have identified new proteins that control the function of critical immune cell subsets called T-cells, which are responsible for a serious and often deadly side effect of lifesaving bone marrow transplants.


These new proteins have not previously been associated with T-cell responses. T-cells help fight infections but also can trigger autoimmune diseases or graft vs. host disease, a side effect of bone marrow transplant in which the new donor cells begin attacking other cells in the patient's body.


"We identified new targets within the T-cells that regulate the immune response to foreign antigens. If these proteins can be targeted, it may prove helpful in reducing graft-vs.-host disease," says study first author Yaping Sun, M.D., Ph.D., internal medicine research investigator at the U-M Medical School.


Reducing the incidence of graft-vs.-host disease could make bone marrow transplant an option for more people with blood-based cancers. About half of people who receive a transplant from donated cells develop graft-vs.-host.


In this study, which is published in the Journal of Clinical Investigation, the researchers looked at the landscape of mRNA and micro-RNA after the T-cells were activated by different kinds of stimuli. mRNA are made from the genes present in the DNA and serve as templates for making proteins. Micro-RNA are also copied from the DNA but do not code for proteins; instead they fine tune the expression of other genes and proteins.


By looking at both simultaneously, the researchers were able to tease out only the mRNAs that were regulated by micro-RNA. They found that two mRNA's that express the proteins Wapal and Synj1 were among the most differentially expressed. Both these proteins have been implicated in other cellular functions, but had not previously been linked to a role in T-cell immune responses.


The researchers validated their findings in laboratory studies to look at T-cell functions in cell cultures and in mice. Importantly, when they blocked the proteins, it impacted the T-cell function and reduced graft-vs.-host disease in mice.


"We know a lot of proteins play a role in T-cell responses. We're adding more to the armory. Our initial validations in mice are preliminary, but a promising start," says senior study author Pavan Reddy, M.D., professor of hematology/oncology at the U-M Medical School.


This research is still in its early stages. No compounds currently are known to target Wapal or Synj1. Additional research is needed.


###

Additional authors: Isao Tawara, Mie University Hospital, Japan; Meng Zhao and Zhaohui S. Qin, Emory University; Tomomi Toubai, Nathan Mathewson, Hiroya Tamaki, Evelyn Nieves, and Arul Chinnaiyan, University of Michigan


Funding: National Institutes of Health grants AI-075284, CA-173878 and HL-090775; clinical research award from the Leukemia Lymphoma Society; basic science investigator award from the American Society of Transplantation


Disclosure: None


Reference: Journal of Clinical Investigation, Vol. 123, No. 11, November 2013


Resources:

U-M Cancer AnswerLine, 800-865-1125

U-M Comprehensive Cancer Center, http://www.mcancer.org

Clinical trials at U-M, http://www.mcancer.org/clinicaltrials



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Newly identified proteins make promising targets for blocking graft-vs.-host disease


[ Back to EurekAlert! ]

PUBLIC RELEASE DATE:

31-Oct-2013



[


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]


Share Share

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System



Finding could help improve outcomes from bone marrow transplants




ANN ARBOR, Mich. Researchers from the University of Michigan Comprehensive Cancer Center have identified new proteins that control the function of critical immune cell subsets called T-cells, which are responsible for a serious and often deadly side effect of lifesaving bone marrow transplants.


These new proteins have not previously been associated with T-cell responses. T-cells help fight infections but also can trigger autoimmune diseases or graft vs. host disease, a side effect of bone marrow transplant in which the new donor cells begin attacking other cells in the patient's body.


"We identified new targets within the T-cells that regulate the immune response to foreign antigens. If these proteins can be targeted, it may prove helpful in reducing graft-vs.-host disease," says study first author Yaping Sun, M.D., Ph.D., internal medicine research investigator at the U-M Medical School.


Reducing the incidence of graft-vs.-host disease could make bone marrow transplant an option for more people with blood-based cancers. About half of people who receive a transplant from donated cells develop graft-vs.-host.


In this study, which is published in the Journal of Clinical Investigation, the researchers looked at the landscape of mRNA and micro-RNA after the T-cells were activated by different kinds of stimuli. mRNA are made from the genes present in the DNA and serve as templates for making proteins. Micro-RNA are also copied from the DNA but do not code for proteins; instead they fine tune the expression of other genes and proteins.


By looking at both simultaneously, the researchers were able to tease out only the mRNAs that were regulated by micro-RNA. They found that two mRNA's that express the proteins Wapal and Synj1 were among the most differentially expressed. Both these proteins have been implicated in other cellular functions, but had not previously been linked to a role in T-cell immune responses.


The researchers validated their findings in laboratory studies to look at T-cell functions in cell cultures and in mice. Importantly, when they blocked the proteins, it impacted the T-cell function and reduced graft-vs.-host disease in mice.


"We know a lot of proteins play a role in T-cell responses. We're adding more to the armory. Our initial validations in mice are preliminary, but a promising start," says senior study author Pavan Reddy, M.D., professor of hematology/oncology at the U-M Medical School.


This research is still in its early stages. No compounds currently are known to target Wapal or Synj1. Additional research is needed.


###

Additional authors: Isao Tawara, Mie University Hospital, Japan; Meng Zhao and Zhaohui S. Qin, Emory University; Tomomi Toubai, Nathan Mathewson, Hiroya Tamaki, Evelyn Nieves, and Arul Chinnaiyan, University of Michigan


Funding: National Institutes of Health grants AI-075284, CA-173878 and HL-090775; clinical research award from the Leukemia Lymphoma Society; basic science investigator award from the American Society of Transplantation


Disclosure: None


Reference: Journal of Clinical Investigation, Vol. 123, No. 11, November 2013


Resources:

U-M Cancer AnswerLine, 800-865-1125

U-M Comprehensive Cancer Center, http://www.mcancer.org

Clinical trials at U-M, http://www.mcancer.org/clinicaltrials



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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.




Source: http://www.eurekalert.org/pub_releases/2013-10/uomh-nip103113.php
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Boston rejoices in World Series victory at home

Boston Red Sox fans celebrate in the street near Fenway Park following Game 6 of baseball's World Series between the Red Sox and the St. Louis Cardinals, Wednesday, Oct. 30, 2013, in Boston. The Red Sox won 6-1 to win the series. (AP Photo/Steven Senne)







Boston Red Sox fans celebrate in the street near Fenway Park following Game 6 of baseball's World Series between the Red Sox and the St. Louis Cardinals, Wednesday, Oct. 30, 2013, in Boston. The Red Sox won 6-1 to win the series. (AP Photo/Steven Senne)







Boston Red Sox fans celebrate after winning the championship over the St. Louis Cardinals in Game 6 of baseball's World Series Thursday, Oct. 31, 2013, in Boston. The Red Sox won 6-1 to win the series. (AP Photo/Elise Amendola)







Boston Red Sox fans celebrate in the street near Fenway Park following Game 6 of baseball's World Series between the Red Sox and the St. Louis Cardinals on Wednesday, Oct. 30, 2013, in Boston. The Red Sox won 6-1 to win the series. (AP Photo/Steven Senne)







Boston Red Sox fans celebrate after Boston defeated the St. Louis Cardinals in Game 6 of baseball's World Series Wednesday, Oct. 30, 2013, in Boston. The Red Sox won 6-1 to win the series. (AP Photo/Charlie Riedel)







Boston Red Sox fans celebrate after Boston defeated St. Louis Cardinals in Game 6 of baseball's World Series Wednesday, Oct. 30, 2013, in Boston. The Red Sox won 6-1 to win the series. (AP Photo/Charlie Riedel)







(AP) — The Red Sox have now won three World Series in the past decade — but not since the days of Babe Ruth had Boston won a fall classic in its beloved Fenway Park.

The victory sent Boston fans spilling into the streets Wednesday night to celebrate the team's 6-1 victory over the St. Louis Cardinals in Game 6. Amid the cheers and high-fives, the white lights of Boston's Prudential Tower read "GO SOX."

"Words cannot describe how I feel," Red Sox fan Sam D'Arrigo said. "This is what being a Boston fan is all about."

The win capped an emotional season for the Red Sox, one heavy with the reminder of the Boston Marathon bombings in April, which left three people dead and more than 260 wounded. Players wore "Boston Strong" logos on their left sleeves and a giant "B Strong" logo was mowed into Fenway's outfield.

"We needed this," said Mark Porcaro of Boston. "They were an easy team to get behind because they stood up for us when we needed them most."

An excited Mayor Tom Menino tweeted: "Get the ducks ready, we're having a parade." He was referring to the duck boat parades the city had had during previous sports celebrations.

Menino and Red Sox officials later announced that the parade would begin at 10 a.m. Saturday at Fenway Park and travel down Boylston Street — where the Marathon attack occurred — before going on to the Charles River. Organizers said they wanted the parade to be held at a time when as many fans, including families with children, could attend.

After the deciding game, police set up barriers to funnel the crowds away from Fenway Park and mounted police and officers on bicycles patrolled the area. Some fans were obviously intoxicated. A few young men climbed a pole holding a traffic light.

A large group gathered near the marathon finish line, chanting and blocking traffic until police arrived.

The Suffolk District Attorney's office reported that Boston and state police made 10 arrests in the city, mostly for disorderly conduct.

Throughout the night, the Boston police department had tweeted cautionary messages, encouraging fans to "Celebrate with pride" and "Celebrate responsibly." Police later thanked the "tens of thousands" of Red Sox fans who took their warnings seriously.

There were no reports of serious damage but at least one car was overturned.

Officials at the University of Massachusetts said 15 people — all but one of them students — were arrested after thousands gathered on the Amherst campus to celebrate the Red Sox win. Most of those arrested were charged with failing to disperse and two also with assault and battery on a police officer. No injuries were reported.

In New Hampshire, celebrations turned destructive at several college campuses. In the largest incident, University of New Hampshire officials say police used pepper spray and pepper balls to break up a crowd of several hundred students that had gathered at the Durham campus. Officials said some of the students threw bottles and cans at officers; five were arrested on disorderly conduct charges.

At Keene State College, police also used pepper spray after students flipped over a vehicle and threw rocks, glass bottles and ice. No one was arrested.

Boston has hosted several celebrations over the last decade as the Celtics, Patriots, Bruins and Red Sox have all won titles since 2004, but some of the post-championship partying has caused problems. In 2004, a 21-year-old college student was killed by a pepper pellet fired by Boston police during crowd-control efforts following the Red Sox win in the American League Championship Series. In 2008, a 22-year-old man died after police took him into custody during street celebrations of the Celtics' title.

In St. Louis, fans were disappointed that the Cardinals lost.

Ed Moreland watched the game while cleaning offices at a downtown bank building. "We had a good team. We fought for it," he said. "Boston was just a bit stronger."

At The Dubliner, an Irish pub near the St. Louis Convention Center, bartender David Fitzgibbons suggested that collective excitement in the city dissipated after a 3-1 loss in Game 5 that left the Cardinals needing a two-game sweep in Boston to prevail.

"I don't think people's expectations were that high," he said.

Wednesday's game was a triumphant end to a hectic day in Boston — hours before the game, President Barack Obama delivered a talk at historic Faneuil Hall on his embattled heath care reform.

With the World Series and a presidential visit, police were on high alert. The marathon bombing prompted the deployment of extra dogs and undercover officers.

For the citizens of Red Sox Nation, the extra security, the traffic and the closed streets were a small price to pay for baseball glory.

"Since 1918, no one has experienced this," said Russ Stappen of Rockland, Mass., who shelled out several hundred dollars for his ticket. "There's nowhere else I'd rather be."

___

Associated Press writers Jay Lindsay and Bob Salsberg in Boston and Alan Scher Zagier in St. Louis contributed to this report.

Associated PressSource: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-10-31-World%20Series-Boston/id-8ec47fcc5c3d4fe4be496b2d6ad90c02
Category: seahawks   emmys   michael beasley   Kelly LeBrock   hell on wheels  

Scare Are They Now? Checking In On Our Favorite Horror Series


We've got the latest updates on some developing entries to the best loved spooky franchises.


By Kevin P. Sullivan








Source:
http://www.mtv.com/news/articles/1716570/horror-film-halloween-franchises.jhtml

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Adobe Hack Victim Count Skyrockets to 38M

"We often become numb to the numbers when discussing breaches, but 38 million is a vastly different scale of breach -- it's massive," explained Tim Erlin, director of IT risk and security strategy with Tripwire. "It surpasses last year's 24 million record Zappos breach and will undoubtedly cost Adobe tens of millions of dollars."


After initially estimating that a mere 3 million customers had been affected by the security breach it announced at the start of October, Adobe on Wednesday admitted that the actual number now looks to be closer to an eye-popping 38 million. In addition, the breach seems to be more far-reaching than initially thought, extending to the Photoshop family of products as well.


In its original announcement, Adobe said hackers stole 3 million encrypted customer credit card records and login data for Adobe user accounts. This past weekend, however, AnonNews.org posted a file that appears to include more than 150 million username and hashed password pairs taken from Adobe, according to Krebs on Security.


So far, Adobe's investigation has confirmed that the attackers obtained access to Adobe IDs and what were at the time valid, encrypted passwords for approximately 38 million active users, the company said in a statement provided to the E-Commerce Times by spokesperson Marissa Hopkins.


"We have completed email notification of these users," Adobe said. "We also have reset the passwords for all Adobe IDs with valid, encrypted passwords that we believe were involved in the incident -- regardless of whether those users are active or not."


Adobe believes the attackers obtained access to many invalid Adobe IDs, inactive Adobe IDs, Adobe IDs with invalid encrypted passwords, and test account data as well, the company added: "We are still in the process of investigating the number of inactive, invalid and test accounts involved in the incident. Our notification to inactive users is ongoing."


There's no indication so far, however, that there has been unauthorized activity on any Adobe ID account involved in the incident, the company pointed out.


38 Million!


As with most security hacks, information is limited and experts are left filling in the blanks with speculation. For example, there is the question of how one breach could encompass so many people.


"We often become numb to the numbers when discussing breaches, but 38 million is a vastly different scale of breach -- it's massive," Tim Erlin, director of IT risk and security strategy at Tripwire, told TechNewsWorld. "It surpasses last year's 24 million record Zappos breach and will undoubtedly cost Adobe tens of millions of dollars.


"As more information about the attack vector and details emerges, we'll be able to understand what Adobe might have done to prevent this compromise," Erlin added.


A breach of this size doesn't happen overnight, noted Craig Young, also a security researcher with Tripwire.


"Clearly, attackers were on Adobe's networks for a prolonged period of time without being detected," Young told TechNewsWorld. "In fact, the attacks were only brought to light when researchers found Adobe's data on a server used by organized cybercriminals."


Very likely, the hackers attacked an account management server that contained most if not all Adobe accounts, suggested Dodi Glenn, a security researcher with ThreatTrack Security.


Adobe has acknowledged publicly that the breach was possible in part due to server-side accessibility and consolidation of security credentials, noted Lockbox CEO Peter Long.


If nothing else, what this breach has served to highlight "is that a strategy of attempting to secure the infrastructure ultimately can be overwhelmed by a consistent and focused attack," Long told TechNewsWorld.


'Should Have Been Prevented'


Given the magnitude of the numbers involved, it is fair to rethink Adobe's after-the-fact approach to the breach.


When it was first revealed, Adobe apologized and offered free yearlong credit monitoring for affected customers. It also made sure the passwords were encrypted and issued a password reset for the accounts that were compromised, Glenn told TechNewsWorld -- all to the good.


However, "the damage is already done," he added. "The leak occurred, and should have been prevented in the first place."


Where Adobe's response could stand improvement is in providing more transparency about what happened, he concluded, "instead of letting people and security groups speculate."


Source: http://www.technewsworld.com/rsstory/79318.html
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ACA Website: Is Government Technology Doomed To Fail?




Audio for this story from Tell Me More will be available at approximately 3:00 p.m. ET.



 



The Obama administration is defending the Affordable Care Act over its faulty website, and reports that Americans are losing insurance coverage because of the law. To sort out the truth from the rumors, host Michel Martin speaks with Mary Agnes Carey of Kaiser Health News and technology developer Clay Johnson.


Source: http://www.npr.org/templates/story/story.php?storyId=242105911&ft=1&f=1001
Category: bitcoin   college football scores  

Need tech support in Russia? Give Edward Snowden a call

So, what happens after you've become an international pariah? The PRISM revelations may rattle along, but the figure who started it all is trying to return to something approaching a normal life. Edward Snowden's lawyer has revealed that, after settling at an undisclosed location in Russia, the NSA ...


Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/VafuL8VRYcA/
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Eagles QB Vick leaves game against Giants

Philadelphia Eagles quarterback Michael Vick (7) reacts after being sacked during the first half of an NFL football game New York Giants Sunday, Oct. 27, 2013, in Philadelphia. (AP Photo/Michael Perez)







Philadelphia Eagles quarterback Michael Vick (7) reacts after being sacked during the first half of an NFL football game New York Giants Sunday, Oct. 27, 2013, in Philadelphia. (AP Photo/Michael Perez)







New York Giants strong safety Antrel Rolle (26) sacks Philadelphia Eagles quarterback Michael Vick (7) during the first half of an NFL football game on Sunday, Oct. 27, 2013, in Philadelphia. (AP Photo/Michael Perez)







Philadelphia Eagles' Michael Vick (7) throws a pass during the first half of an NFL football game against the New York Giants on Sunday, Oct. 27, 2013, in Philadelphia. (AP Photo/Matt Rourke)







(AP) — Philadelphia Eagles quarterback Michael Vick was pulled Sunday against the New York Giants in his first start since he injured his left hamstring on Oct. 6.

Vick was replaced by Matt Barkley late in the second quarter. Vick was 6 of 9 for 31 yards and threw an interception on Philadelphia's drive of the game. He had little mobility and did not appear close to recovered. He missed the last two games.

Vick rode the stationary bike between drives while Barkley warmed up on the sideline for most of the second quarter.

Barkley replaced Vick with the Eagles trailing 12-0. Vick sat on the bench with a towel on his head for Barkley's first snap.

Nick Foles, who started last week for the Eagles, was inactive after he suffered a concussion.

Associated PressSource: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-10-27-Eagles-Vick%20Out/id-3d2a0fd9fa8f49b0a7a49a558b3f3095
Category: Jenna Jameson   Benedict Cumberbatch   big bang theory   Solheim Cup 2013   Jake Pavelka  

Farrell's steady hand leads Sox to World Series

Boston Red Sox manager John Farrell speaks during a news conference before a workout at Fenway Park in Boston, Tuesday, Oct. 29, 2013. The Red Sox are scheduled to host the St. Louis Cardinals in Game 6 of baseball's World Series on Wednesday. (AP Photo/Elise Amendola)







Boston Red Sox manager John Farrell speaks during a news conference before a workout at Fenway Park in Boston, Tuesday, Oct. 29, 2013. The Red Sox are scheduled to host the St. Louis Cardinals in Game 6 of baseball's World Series on Wednesday. (AP Photo/Elise Amendola)







Boston Red Sox manager John Farrell watches during practice before Game 3 of baseball's World Series against the St. Louis Cardinals Saturday, Oct. 26, 2013, in St. Louis. (AP Photo/Charlie Neibergall)







Boston Red Sox manager John Farrell laughs as he watches his team during baseball practice on Friday, Oct. 25, 2013, in St. Louis. The Red Sox and the St. Louis Cardinals are set to play Game 3 of the World Series, Saturday in St. Louis. (AP Photo/Jeff Roberson)







Boston Red Sox starting pitcher Jon Lester (31) is taken out of the game by manager John Farrell during the eighth inning of Game 5 of baseball's World Series Monday, Oct. 28, 2013, in St. Louis. (AP Photo/Charlie Riedel)







Boston Red Sox manager John Farrell talks to Shane Victorino after Victorino was hit by a pitch during the eighth inning of Game 3 of baseball's World Series against the St. Louis Cardinals Saturday, Oct. 26, 2013, in St. Louis. (AP Photo/Jeff Roberson)







(AP) — John Farrell failed in his last managerial job. The Boston Red Sox had their worst record in nearly a half century.

After a dismal 2012 season for both, they're together now and that past seems so far away.

It's a match made for the World Series.

"I try to live out what our team has lived out this year and, that is, not to look back," Farrell said.

Why would he want to?

The Toronto Blue Jays were 73-89 last season, their second under Farrell, and actually trailed Boston in the standings with 10 games left. Then the Red Sox finally won something — the race to the bottom of the AL East. They lost nine of their last 10 games, dropping to 69-93 and insuring that Bobby Valentine's tumultuous term as manager would end after one season.

Enter Farrell.

He had one year left on his contract with the Blue Jays so the Red Sox had to trade to get their old pitching coach back to run the show as manager.

His impact was immediate in spring training, the transition smoothed by his familiarity with many of his players.

"He came in there with a presence," pitching ace Jon Lester said, "Came in there with his idea of how he wanted to run this team and stood up there in front of us and told us how he wanted it done.

"And I think the 40 guys or whatever that was in that room kind of looked around and it was like, 'OK, let's go do it.' "

So they did, with a consistency and clubhouse cohesion missing from Valentine's Way.

The Red Sox spent an AL-best 158 days in first place, were one of two major-league teams above .500 all year and had no losing streak longer than three games for just the second time in their 113 seasons.

And the players bonded long before their beards blossomed.

Gone were highly paid disgruntled players like Adrian Gonzalez, Carl Crawford and Josh Beckett. In their place were team-oriented hustlers like Jonny Gomes, Mike Napoli, Shane Victorino, Stephen Drew and David Ross.

But it took the even-keeled Farrell and his communication skills to bring them all together after Valentine's shoot-from-the-lip style failed.

"The thing with John is he's so smart. I think it seems like he learns from every single person he's around in baseball," second baseman Dustin Pedroia said. "John this year has been unbelievable with all of us, just the communication."

At 6-foot-4, the broad-shouldered Farrell has a military bearing. He leads his players and listens to them. He lets them know their roles, explains why they're not in the lineup and sees them produce off the bench.

Before World Series games, he sits at an interview table, rarely blinking as he listens closely to questions. Then he answers thoughtfully, occasionally breaking into a smile.

And he's not afraid to admit that he's wrong.

With Game 3 tied 4-4 with one out in the top of the ninth, Farrell let Brandon Workman bat with one out rather than have Napoli pinch hit and make a double-switch at first base and pitcher.

Workman struck out. Then he left the game with one out and a runner at first in the bottom of the ninth when the Cardinals won 5-4 on an obstruction play.

"In retrospect, sure, I would have liked to (use a pinch hitter)," Farrell said. "Still, I wasn't going to pinch-hit for Workman with no guarantee that Napoli drives one out of the ballpark."

He also handles critics — there haven't been many in Boston — with respect.

When he was booed by fans on his return to Toronto with Boston on April 4, Farrell said, "That goes back to how much people care, and that's a good thing.

"Unfortunately, over the past couple of years, some things didn't play out on the field as we had hoped."

But now he's in Boston where his philosophy is working out just fine.

"There's a relentless approach to play a complete game every night," Farrell said. "That attitude is what has allowed us to come back from so many deficits this year and never give an at-bat away, and certainly play to the 27th out every night."

Unlike his predecessor, in Boston he has a strong relationship with his coaches and doesn't call attention to himself by criticizing players.

Farrell hired Juan Nieves as his pitching coach then stayed out of his way despite having served in that role with the Red Sox from 2007-2010. The staff ERA of 3.79 was nearly a run less than last season's and Boston's best in 11 years.

"His genuineness as a person to me was the one thing that would allow him to connect with players," Farrell said of Nieves.

Just like Farrell.

From that first meeting in spring training.

"Nobody had any questions," Lester said. "It was our job to go out there and do what he told us to do. And I think we've done a good job of that."

Associated PressSource: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-10-30-BBO-World-Series-Red-Sox-Farrell/id-a9d01ee86cd846c0822d21c50b776897
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NSA Infiltrates Google And Yahoo Networks, Report Says


The National Security Agency has secretly taped the networks of Google and Yahoo to monitor real-time communication, according to newly revealed documents from whistleblower, Edward Snowden [PDF].


“The National Security Agency has secretly broken into the main communications links that connect Yahoo and Google data centers around the world, according to documents obtained from former NSA contractor Edward Snowden and interviews with knowledgeable officials,” according to The Washington Post, which obtained the hand-scribbled documents.


Both Google and Yahoo maintain expensive fiber-optic data linkages in strategic data centers around the world to optimize the flow of information. This infiltration would allow the NSA to know “who sent or received e-mails and when, to content such as text, audio and video.”


Upon learning about the NSA tapping into their networks, Google released a statement, saying the company is “troubled by allegations of the government intercepting traffic between our data centers, and we are not aware of this activity.”


Codenamed, MUSCULAR, the surveillance project is operated jointly with British Intelligence agency, GCHQ.


While the NSA already had access to communication through court-sanctioned collection program PRISM, the agency may prefer international territory because it permits them to subvert American privacy law. The NSA is forbidden from spying on Americans without stringent court oversight; international law may be less restrictive.


The Post reports that upon showing this information to two engineers familiar with Google’s system, they “exploded in profanity” and said “I hope you publish this.”



Source: http://feedproxy.google.com/~r/Techcrunch/~3/c0MMH5WltOk/
Category: Panda Express   pirate bay   2020 Olympics  

MUHC researchers identify biomarkers that could lead to early diagnosis of colorectal cancer

MUHC researchers identify biomarkers that could lead to early diagnosis of colorectal cancer


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PUBLIC RELEASE DATE:

30-Oct-2013



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Contact: Julie Robert
julie.robert@muhc.mcgill.ca
514-934-1934 x71381
McGill University Health Centre





This news release is available in French.


MONTREAL, October 30, 2013 Diagnosing colorectal cancer (CRC) is complex; it relies on significant invasive tests and subjective evaluations. This process may soon become much easier thanks to a medical breakthrough by scientists at the Research Institute of the McGill University Health Centre (RI-MUHC). The researchers have identified genetic changes in the colon lining, or mucosa, in colorectal cancer patients that could be used as biomarkers of the disease. That will allow doctors to diagnose patients earlier, more accurately and less invasively. The study, recently published online, in Cancer Prevention Research, has implications for the nearly one million people diagnosed annually worldwide.


"The gold standard of diagnosis is currently colonoscopy," says corresponding author of the study, Dr. Rima Rozen, a geneticist from the Departments of Human Genetics and Pediatrics at The Montreal Children's Hospital of the MUHC and McGill University. "This is an invasive procedure, where the physician looks for abnormal tissue or growths also known as polyps." Additionally, given surging demand for colonoscopies, this research may ultimately offer an alternative option for early diagnosis, paving the way for the reduction in wait time.


According to Dr. Rozen, who is also a researcher of the Medical Genetics and Genomics Axis at the RI-MUHC, having genetic biomarkers of CRC will enhance the diagnostic procedure. "This new method could help to avoid false negative findings, which can occur in 10 to 15 per cent of endoscopic procedures," she says. "The key is using the right genes. I believe the ones we have identified are good candidates."


Dr. Rozen and her colleagues first identified five possible abnormal marker genes in a colon cancer mouse model. They then confirmed that these candidate biomarker genes were also abnormal in tissue obtained from colon cancer patients. "Not only did this show that our mouse model mimics the human disease," says Dr. Rozen. "But more importantly, it identified genes that could be used for colorectal cancer diagnosis."


Interestingly, the abnormal patterns of these genes were detected in otherwise normal colon cells that were not near the tumor site. "CRC develops in different stages," says Dr. Rozen. "This finding suggests that it may be possible to take tissue samples in more accessible regions of the gastrointestinal tract or, ideally, in blood or stool, and look for biomarkers as an early indicator of disease."


###

About colorectal cancer

Colorectal cancer also known as bowel or colon cancer refers to the abnormal cell growth in the colon (intestine) and rectum. The abnormal cells can develop into benign (non-cancerous) tumours called polyps. Although not all polyps develop into colorectal cancer, colorectal cancer almost always develops from a polyp. Over time, genes in the polyp mutate and cells within them become malignant (cancerous). Colorectal cancer is the most common cancer in developed countries.


About the study:

The study, Genes with aberrant expression in murine preneoplastic intestine show epigenetic and expression changes in normal mucosa of colon cancer patients, was co-authored by Daniel Leclerc, Nancy Lvesque, Yuanhang Cao, Liyuan Deng, Qing Wu, and Rima Rozen of the RI-MUHC, Montreal and Jasmine Powell and Carmen Sapienza of the Temple University School of Medicine, Philadelphia.


This research was made possible thanks to funding from the Canadian Institutes of Health Research (CIHR).


Related links:

For more information please contact:


Julie Robert

Public Affairs and Strategic Planning

McGill University Health Centre

t: 514-843-1560

e: julie.robert@muhc.mcgill.ca

facebook.com/cusm.muhc | http://www.muhc.ca




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MUHC researchers identify biomarkers that could lead to early diagnosis of colorectal cancer


[ Back to EurekAlert! ]

PUBLIC RELEASE DATE:

30-Oct-2013



[


| E-mail

]


Share Share

Contact: Julie Robert
julie.robert@muhc.mcgill.ca
514-934-1934 x71381
McGill University Health Centre





This news release is available in French.


MONTREAL, October 30, 2013 Diagnosing colorectal cancer (CRC) is complex; it relies on significant invasive tests and subjective evaluations. This process may soon become much easier thanks to a medical breakthrough by scientists at the Research Institute of the McGill University Health Centre (RI-MUHC). The researchers have identified genetic changes in the colon lining, or mucosa, in colorectal cancer patients that could be used as biomarkers of the disease. That will allow doctors to diagnose patients earlier, more accurately and less invasively. The study, recently published online, in Cancer Prevention Research, has implications for the nearly one million people diagnosed annually worldwide.


"The gold standard of diagnosis is currently colonoscopy," says corresponding author of the study, Dr. Rima Rozen, a geneticist from the Departments of Human Genetics and Pediatrics at The Montreal Children's Hospital of the MUHC and McGill University. "This is an invasive procedure, where the physician looks for abnormal tissue or growths also known as polyps." Additionally, given surging demand for colonoscopies, this research may ultimately offer an alternative option for early diagnosis, paving the way for the reduction in wait time.


According to Dr. Rozen, who is also a researcher of the Medical Genetics and Genomics Axis at the RI-MUHC, having genetic biomarkers of CRC will enhance the diagnostic procedure. "This new method could help to avoid false negative findings, which can occur in 10 to 15 per cent of endoscopic procedures," she says. "The key is using the right genes. I believe the ones we have identified are good candidates."


Dr. Rozen and her colleagues first identified five possible abnormal marker genes in a colon cancer mouse model. They then confirmed that these candidate biomarker genes were also abnormal in tissue obtained from colon cancer patients. "Not only did this show that our mouse model mimics the human disease," says Dr. Rozen. "But more importantly, it identified genes that could be used for colorectal cancer diagnosis."


Interestingly, the abnormal patterns of these genes were detected in otherwise normal colon cells that were not near the tumor site. "CRC develops in different stages," says Dr. Rozen. "This finding suggests that it may be possible to take tissue samples in more accessible regions of the gastrointestinal tract or, ideally, in blood or stool, and look for biomarkers as an early indicator of disease."


###

About colorectal cancer

Colorectal cancer also known as bowel or colon cancer refers to the abnormal cell growth in the colon (intestine) and rectum. The abnormal cells can develop into benign (non-cancerous) tumours called polyps. Although not all polyps develop into colorectal cancer, colorectal cancer almost always develops from a polyp. Over time, genes in the polyp mutate and cells within them become malignant (cancerous). Colorectal cancer is the most common cancer in developed countries.


About the study:

The study, Genes with aberrant expression in murine preneoplastic intestine show epigenetic and expression changes in normal mucosa of colon cancer patients, was co-authored by Daniel Leclerc, Nancy Lvesque, Yuanhang Cao, Liyuan Deng, Qing Wu, and Rima Rozen of the RI-MUHC, Montreal and Jasmine Powell and Carmen Sapienza of the Temple University School of Medicine, Philadelphia.


This research was made possible thanks to funding from the Canadian Institutes of Health Research (CIHR).


Related links:

For more information please contact:


Julie Robert

Public Affairs and Strategic Planning

McGill University Health Centre

t: 514-843-1560

e: julie.robert@muhc.mcgill.ca

facebook.com/cusm.muhc | http://www.muhc.ca




[ Back to EurekAlert! ]

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.




Source: http://www.eurekalert.org/pub_releases/2013-10/muhc-mri102913.php
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Senate hearing to explore security clearances

FILE - In this Sept. 18, 2013 file photo, employees of the Washington Navy Yard line up to enter through a gate two days after a gunman killed twelve people and was killed himself inside. A new report says contract guards who protect federal facilities are receiving uneven training on responding to shootings like the one last month at the Washington Navy Yard. The report was released Wednesday by the Government Accountability Office. A summary of the report was presented at a House subcommittee hearing on securing federal facilities. The report says officials at five guard companies said their guards had not received training on what to do when a gunman is opening fire. (AP Photo/Jacquelyn Martin, File)







FILE - In this Sept. 18, 2013 file photo, employees of the Washington Navy Yard line up to enter through a gate two days after a gunman killed twelve people and was killed himself inside. A new report says contract guards who protect federal facilities are receiving uneven training on responding to shootings like the one last month at the Washington Navy Yard. The report was released Wednesday by the Government Accountability Office. A summary of the report was presented at a House subcommittee hearing on securing federal facilities. The report says officials at five guard companies said their guards had not received training on what to do when a gunman is opening fire. (AP Photo/Jacquelyn Martin, File)







WASHINGTON (AP) — Federal officials who oversee the security clearance process for government employees were to face a Senate committee investigating the events leading up to a deadly shooting at the Washington Navy Yard.

The hearing Thursday before the Senate Committee on Homeland Security and Governmental Affairs is to examine the adequacy of background checks and the security clearance system for federal employees and contract workers. It comes as officials investigate how Aaron Alexis, a 34-year-old defense contractor, was able to acquire and maintain a secret clearance despite a series of violent outbursts, repeated brushes with the law and concerns about his mental health.

The former Navy reservist killed 12 people inside the Navy Yard building where he worked Sept. 16 before being fatally shot by police. He entered the property with a valid security badge.

"The tragic events at the Navy Yard highlight the need to be ever-vigilant in ensuring that individuals entrusted with access to classified information, and, more generally, other individuals with logical and physical access to federal facilities and information do not present either a national security risk or a personal security risk," Elaine Kaplan said in remarks prepared for the Senate hearing. Kaplan is acting director of the Office of Personnel Management, which oversees more than 90 percent of background investigations for the federal government.

President Barack Obama has also ordered the White House budget office to examine security standards for government contractors and employees across federal agencies. Concerns about weaknesses in the security clearance system have surfaced not only with Alexis but also with National Security Agency leaker Edward Snowden and Army Pvt. Chelsea Manning, currently imprisoned for leaking classified documents.

"Many national security experts have long argued that the security clearance process is antiquated and in need of modernization. Given recent events, I think we have to ask whether the system is fundamentally flawed," Sen. Tom Carper, the committee chairman, said in prepared remarks.

Defense officials have said that when Alexis applied for security clearance with the Navy, he lied about a 2004 arrest in Seattle for shooting the tires of an unoccupied vehicle and he failed to disclose thousands of dollars in debts. An FBI fingerprint check revealed the arrest, but an investigative report from an OPM contractor omitted the fact that Alexis had fired shots, the Seattle police department did not turn over records of the arrest and no charges were filed.

He was granted a secret clearance in 2008 and held onto it despite multiple subsequent encounters with police, including a 2010 arrest in Texas, where a neighbor told police she was nearly struck by a bullet fired from his downstairs apartment. No charges were filed.

Kaplan said her staff has advised her that Alexis's file "complied with all applicable standards," but that OPM's office of internal oversight and compliance is reviewing the matter.

One month before the Navy Yard shooting, Alexis called police in Rhode Island to the hotel where he was staying and complained about voices wanting to harm him, according to the police report. The FBI has said he believed he was being bombarded with extremely low frequency radio waves.

Four senators on Wednesday introduced legislation to require more frequent checks on government employees and contractors who are awarded security clearances. Clearances last for five or 10 years depending on the level of secrecy required in the job and the level of clearance.

The bill requires OPM to do at least two audits of every security clearance at random times over each five years the clearance is in effect. Surprise audits would send the message that "you never know when the government is going to find out," so it's better to come forward with the information voluntarily, said one sponsor, Democratic Sen. Claire McCaskill of Missouri.

___

Associated Press writer Pauline Jelinek contributed to this report.

Associated PressSource: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-10-31-US-Navy-Yard-Shooting-Security-Clearances/id-b65bf31b98f549599a3478c1bb359906
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